TY - JOUR
PY - 2018//
TI - Changes in [18F]fluorodeoxyglucose activities in a shockwave-induced traumatic brain injury model using lithotripsy
JO - Journal of neurotrauma
A1 - Divani, Afshin Andre
A1 - Phan, Jenny-Ann
A1 - Salazar, Pascal
A1 - SantaCruz, Karen S.
A1 - Bachour, Ornina
A1 - Mahmoudi, Javad
A1 - Zhu, Xiao-Hong
A1 - Pomper, Martin
SP - 187
EP - 194
VL - 35
IS - 1
N2 - We present a longitudinal study of cerebral metabolism using [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) in a rat model of shockwave-induced traumatic brain injury (SW-TBI). Anesthetized rats received 5 or 10 shockwave pulses to the right anterior lateral or dorsal frontal regions using shockwave lithotripsy. Animals were scanned for FDG uptake at baseline, 3 hours post-injury, and 3 days post-injury, using a small animal PET/CT scanner. FDG uptake at all time points was quantified as the ratio of brain activity relative to peripheral activity in the left ventricle (LV) in the heart (Abrain/ALV) for the entire brain, each hemisphere, and four cortices (motor, cingulate, somatosensory, and restrosplenial). The mixed-designed models ANOVA for the hemispheric and global FDG uptake ratio showed a significant effect of the time-of-scan (P=0.038) and measured region (P=6.12e-09). We also observed a significant effect of the time-of-scan (P=0.046) and measured region (P=2.28e-09) for the FDG uptake ratio in four cortical regions. None of the measurements (global or local) showed a significant effect for the number of shockwave pulses (5 or 10) or shockwave location (lateral or dorsal frontal regions). Our data suggest that SW-TBI causes hypermetabolism on the impact side of the rat brain at 3 hours post-injury compared to the baseline measurements. However, the increase in FDG uptake by day 3 post-injury was not significant. Further studies on post-TBI metabolic changes are needed to understand better the pathophysiology of the injury. Language: en
LA - en
SN - 0897-7151
UR - http://dx.doi.org/
ID - ref1
ER -