TY  - JOUR
PY  - 2017//
TI  - The chronic and evolving neurological consequences of traumatic brain injury
JO  - Lancet neurology
A1  - Wilson, Lindsay
A1  - Stewart, William
A1  - Dams-O'connor, Kristen
A1  - Diaz-Arrastia, Ramon
A1  - Horton, Lindsay
A1  - Menon, David K.
A1  - Polinder, Suzanne
SP  - 813
EP  - 825
VL  - 16
IS  - 10
N2  - Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke, and neurodegenerative disease. With respect to neurodegeneration after TBI, post-mortem studies on the long-term neuropathology after injury have identified complex persisting and evolving abnormalities best described as polypathology, which includes chronic traumatic encephalopathy. Despite growing awareness of the lifelong consequences of TBI, substantial gaps in research exist. Improvements are therefore needed in understanding chronic pathologies and their implications for survivors of TBI, which could inform long-term health management in this sizeable patient population.<br><br>Copyright © 2017 Elsevier Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1474-4422
UR  - http://dx.doi.org/10.1016/S1474-4422(17)30279-X
ID  - ref1
ER  -