TY  - JOUR
PY  - 2018//
TI  - Longitudinal study of a NoGo-P3 event-related potential component following mild traumatic brain injury in adults
JO  - Annals of physical and rehabilitation medicine
A1  - Candrian, Gian
A1  - Müller, Andreas
A1  - Dall'Acqua, Patrizia
A1  - Kompatsiari, Kyveli
A1  - Baschera, Gian-Marco
A1  - Mica, Ladislav
A1  - Simmen, Hans-Peter
A1  - Glaab, Richard
A1  - Fandino, Javier
A1  - Schwendinger, Markus
A1  - Meier, Christoph
A1  - Ulbrich, Erika Jasmin
A1  - Johannes, Sönke
SP  - 18
EP  - 26
VL  - 61
IS  - 1
N2  - BACKGROUND: Event-related potentials have repeatedly revealed electrophysiological markers of cognitive dysfunction associated with Mild Traumatic Brain Injury (MTBI) and may represent a sensitive tool to guide cognitive rehabilitative interventions. We previously found patients with symptomatic MTBI characterized by smaller P300 (or P3) wave amplitudes in a NoGo-P3 subcomponent in the acute phase of the injury. The goal of this longitudinal study was to investigate whether this early NoGo-P3 subcomponent differs over time in symptomatic MTBI patients and healthy controls. <br><br>METHODS: We included adults with a diagnosis of MTBI and individually matched healthy controls tested at 1 week, 3 months, and 1 year after the MTBI. Symptoms were assessed by the Rivermead Post-Concussion Symptoms Questionnaire. NoGo-P3 was collected by using a cued Go/NoGo task and the relevant subcomponent was extracted by independent component analysis. <br><br>RESULTS: Among 53 adults with a diagnosis of MTBI and 53 controls, we included 35 with symptomatic MTBI and 35 matched healthy controls (18 females each group; mean age 34.06±13.15 and 34.26±12.98 years). Amplitudes for the early NoGo-P3 subcomponent were lower for symptomatic MTBI patients than controls (P<0.05) at 1 week post-injury. Furthermore, mixed ANOVA revealed a significant time by group interaction (P<0.05), so the effect of time differed for symptomatic MTBI patients and healthy controls. The amplitudes for MTBI patients normalized from 1 week to 3 months post-injury and were comparable to those of controls from 3 months to 1 year post-injury. However, amplitudes for 3 MTBI patients with particularly severe complaints 1 year post-injury did not normalize and were lower than those for the remaining MTBI sample (P<0.05). <br><br>CONCLUSIONS: Selected event-related potentials can be used as a sensitive and objective tool to illustrate the cognitive consequences of and recovery after MTBI.<br><br>Copyright © 2017 Elsevier Masson SAS. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1877-0657
UR  - http://dx.doi.org/10.1016/j.rehab.2017.07.246
ID  - ref1
ER  -