TY  - JOUR
PY  - 2017//
TI  - Aggressiveness in depression: a neglected symptom possibly associated with bipolarity and mixed features
JO  - Acta psychiatrica Scandinavica
A1  - Verdolini, N.
A1  - Perugi, G.
A1  - Samalin, L.
A1  - Murru, A.
A1  - Angst, J.
A1  - Azorin, J-M
A1  - Bowden, C. L.
A1  - Mosolov, S.
A1  - Young, A. H.
A1  - Barbuti, M.
A1  - Guiso, G.
A1  - Popović, D.
A1  - Vieta, E.
A1  - Pacchiarotti, I.
SP  - 362
EP  - 372
VL  - 136
IS  - 4
N2  - OBJECTIVE: To evaluate aggressiveness during a major depressive episode (MDE) and its relationship with bipolar disorder (BD) in a post hoc analysis of the BRIDGE-II-MIX study. <br><br>METHOD: A total of 2811 individuals were enrolled in this multicenter cross-sectional study. MDE patients with (MDE-A, n = 399) and without aggressiveness (MDE-N, n = 2412) were compared through chi-square test or Student's t-test. A stepwise backward logistic regression model was performed. <br><br>RESULTS: MDE-A group was more frequently associated with BD (P < 0.001), while aggressiveness was negatively correlated with unipolar depression (P < 0.001). At the logistic regression, aggressiveness was associated with the age at first depressive episode (P < 0.001); the severity of mania (P = 0.03); the diagnosis of BD (P = 0.001); comorbid borderline personality disorder (BPD) (P < 0.001) but not substance abuse (P = 0.63); no current psychiatric treatment (P < 0.001); psychotic symptoms (P = 0.007); the marked social/occupational impairment (P = 0.002). The variable most significantly associated with aggressiveness was the presence of DSM-5 mixed features (P < 0.001, OR = 3.815). After the exclusion of BPD, the variable of lifetime suicide attempts became significant (P = 0.013, OR = 1.405). <br><br>CONCLUSION: Aggressiveness seems to be significantly associated with bipolar spectrum disorders, independently from BPD and substance abuse. Aggressiveness should be considered as a diagnostic criterion for the mixed features specifier and a target of tailored treatment strategy.<br><br>© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0001-690X
UR  - http://dx.doi.org/10.1111/acps.12777
ID  - ref1
ER  -