TY  - JOUR
PY  - 2017//
TI  - Genetic associations and interactions between the NR3C1 (GR) and NR3C2 (MR) genes and aggressive behavior in a Central South Chinese Han Population
JO  - Genetic testing and molecular biomarkers
A1  - Li, Jianming
A1  - Tang, Liang
A1  - Wang, Yan
A1  - Li, Fang
A1  - Bao, Meihua
A1  - Xiang, Ju
A1  - Lei, Deliang
A1  - Tang, Beisha
SP  - 497
EP  - 505
VL  - 21
IS  - 8
N2  - AIMS: The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) play important roles in hypothalamic-pituitary-adrenal axis and stress regulation. The current study aimed to address the genetic association and gene-gene interactions between GR and MR gene polymorphisms and aggressive behavior. <br><br>METHODS: A haplotype-based, case-control study was designed to examine the association between human MR and GR genes and aggressive behaviors, including robbery and intentional interpersonal injury, in a central south Chinese Han population. Eight well-studied polymorphisms of the MR gene (rs2070951, rs2871, rs5522, and rs5525) and the GR gene (rs10482605, rs6190, rs1800445, and rs6196) were genotyped using SNaPshot. <br><br>RESULTS: The MR and GR gene polymorphisms were not associated with aggressive behaviors, including in robbery and intentional interpersonal injury subgroups (p > 0.05). The frequency of haplotype TAAT of GR was significantly higher in the control group than that in the case group (p = 0.004, padj = 0.02). In addition, a two-way interaction between GR rs1800445 and MR rs2070951 and aggressive behavior was also found (p = 0.01). <br><br>CONCLUSIONS: The haplotype TAAT of GR might be a protective factor against aggressive behavior, while gene-gene interactions between GR rs1800445 and MR rs2070951 might be a risk factor for aggressive behavior in the Central South Chinese Han population.<p />  <p>Language: en</p>
LA  - en
SN  - 1945-0265
UR  - http://dx.doi.org/10.1089/gtmb.2016.0417
ID  - ref1
ER  -