TY  - JOUR
PY  - 2018//
TI  - Brain volumetric correlates of inhibition and cognitive flexibility 16 years following childhood traumatic brain injury
JO  - Journal of Neuroscience Research
A1  - Yu, Kelleynne
A1  - Seal, Marc L.
A1  - Reyes, Jonathan
A1  - Godfrey, Celia
A1  - Anderson, Vicki
A1  - Adamson, Chris
A1  - Ryan, Nicholas Peter
A1  - Hearps, Stephen J. C.
A1  - Catroppa, Cathy
SP  - 642
EP  - 651
VL  - 96
IS  - 4
N2  - Executive functions (EFs), such as inhibition and cognitive flexibility, are essential for everyday functioning, including regulation of socially appropriate emotional responses. These skills develop during childhood and continue maturing into early adulthood. The current study aimed to investigate the very long-term impact of childhood traumatic brain injury (TBI) on inhibition and cognitive flexibility, and to examine whether global white matter is associated with these abilities. Twenty-eight young adult survivors of childhood TBI (mean age at 16-year follow-up = 21.67 years, SD = 2.70) and 16 typically developing controls (TDCs), group-matched for age, sex, and socioeconomic status, completed tests of inhibition and cognitive flexibility and underwent structural MRI. Survivors of childhood TBI did not significantly differ from TDCs on EF or white matter volume. However, the relationship between EF and white matter volume differed between survivors of TBI and TDCs. Survivors of TBI did not mimic the brain behavior relationship that characterized EF in TDCs. The inverse brain behavior relationship, exhibited by childhood TBI survivors, suggests disruptions in the whole brain underpinning EF following childhood TBI.<br><br>© 2017 Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 0360-4012
UR  - http://dx.doi.org/10.1002/jnr.24087
ID  - ref1
ER  -