TY  - JOUR
PY  - 2018//
TI  - Transcriptional changes in the mouse retina following ocular blast injury: a role for the immune system
JO  - Journal of neurotrauma
A1  - Struebing, Felix L.
A1  - King, Rebecca
A1  - Li, Ying
A1  - Chrenek, Micah A.
A1  - Lyuboslavsky, Polina N.
A1  - Sidhu, Curran S.
A1  - Iuvone, P. Michael
A1  - Geisert, Eldon E.
SP  - 118
EP  - 129
VL  - 35
IS  - 1
N2  - Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal RNA expression in 54 mouse strains five days after a single 50psi overpressure air wave blast injury. We observe that almost 40% of genes are differentially expressed with a false discovery rate of <0.001, even though the nominal changes in RNA expression are rather small. Moreover, we find through machine learning approaches that genetic networks related to the innate and acquired immune system are activated. Accompanied by lymphocyte invasion into the inner retina, blast injury also results in progressive loss of visual function and retinal ganglion cells. Collectively, these data demonstrate how systems genetics can be used to put meaning to the transcriptome changes following ocular blast injury that eventually lead to blindness.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2017.5104
ID  - ref1
ER  -