TY  - JOUR
PY  - 2017//
TI  - Targeting and transforming major depression
JO  - Acta psychiatrica Scandinavica
A1  - Parker, G.
A1  - Paterson, A.
A1  - McCraw, S.
A1  - Hadzi-Pavlovic, D.
SP  - 310
EP  - 318
VL  - 135
IS  - 4
N2  - OBJECTIVE    To detail limitations to the construct of 'major depression', argue for repositioning it as a proxy for 'clinical depression' and then operationalize it and its principal constituent depressive subtypes, while preserving the DSM criteria-based format.       Method    We summarize limitations to major depression being viewed as a diagnostic entity. Data from 391 clinically depressed patients were analysed to identify high-prevalence non-specific depressive symptoms to define 'clinical depression' as well as the features showing specificity to a melancholic depressive subtype.       Results    We identified a set of high-prevalence and generalized symptoms for defining clinical depression and with many being current criteria for major depression. We also developed a refined set of melancholic features and with their underlying distributions generating two classes that correlated strongly with clinical diagnoses of a melancholic or non-melancholic depression, thus validating its capacity to so differentiate. We append criteria sets for diagnosing clinical depression and its principal diagnostic subtypes (psychotic, melancholic and non-melancholic).       Conclusion    This heuristic study reframes and modifies major depression's criteria set to define a domain of clinical depression with additional criteria and then allowing the delineation of three diagnostic subtypes. If this paradigm shift is accepted and further refined, greater precision in diagnosis, treatment and research would be anticipated.<p />  <p>Language: en</p>
LA  - en
SN  - 0001-690X
UR  - http://dx.doi.org/10.1111/acps.12681
ID  - ref1
ER  -