TY  - JOUR
PY  - 2017//
TI  - New directions for the treatment of depression: targeting the photic regulation of arousal and mood (PRAM) pathway
JO  - Depression and anxiety
A1  - Bowrey, Hannah E.
A1  - James, Morgan H.
A1  - Aston-Jones, Gary
SP  - 588
EP  - 595
VL  - 34
IS  - 7
N2  - Both preclinical and clinical studies demonstrate that depression is strongly associated with reduced light availability, which in turn contributes to decreased function of brain regions that control mood. Here, we review findings that support a critical pathway for the control of mood that depends upon ambient light. We put forward a novel hypothesis, functionally linking retina to locus coeruleus (LC) in depression, and discuss the role of norepinephrine in affective disease. Finally, we discuss how utilizing the chemogenetic tool Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to precisely control this retina-LC circuit may be used as a novel therapeutic to treat depression.<br><br>© 2017 Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 1091-4269
UR  - http://dx.doi.org/10.1002/da.22635
ID  - ref1
ER  -