TY  - JOUR
PY  - 2017//
TI  - The impact of currently recommended antihypertensive therapy on depression and other psychometric parameters: preliminary communication
JO  - Neuropsychopharmacologia Hungarica
A1  - Korosi, Beata
A1  - László, Andrea
A1  - Tabak, Adam
A1  - Batta, Dora
A1  - Lenart, Lilla
A1  - Fekete, Andrea
A1  - Eorsi, Daniel
A1  - Cseprekal, Orsolya
A1  - Tisler, Andras
A1  - Nemcsik-Bencze, Zsofia
A1  - Gonda, Xenia
A1  - Rihmer, Zoltan
A1  - Nemcsik, Janos
SP  - 11
EP  - 22
VL  - 19
IS  - 1
N2  - AIMS: Current evidence on the psychological effects of antihypertensive medications is controversial. The aim of this study was to evaluate the effect of current antihypertensive medication on different psychometric parameters and on serum brain-derived neurotrophic factor (BDNF) level. <br><br>METHODS: Psychometric, haemodynamic, arterial stiffness and laboratory parameters were evaluated before and 3 months after the initiation of antihypertensive medication in untreated hypertensive patients (HT, n=31), and once in healthy controls (CONT, n=22). Subjects completed the following psychometric tests: Beck Depression Inventory (BDI), Hamilton Anxiety Scale (HAM-A), Symptom Checklist 90 Revised (SCL-90), Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire, Big Five Inventory, Pain Vigilance and Awareness Questionnaire and Berkeley Expressivity Questionnaire. Amlodipine and/or perindopril compounds were preferred medications. Serum BDNF was measured with ELISA. <br><br>RESULTS: Brachial systolic blood pressure, as well as pulse wave velocity were significantly improved in the HT group over the 3-month follow-up (153.3±15.9 mmHg vs. 129.5±10.0 mmHg and 8.2±1.4 m/s vs 7.5±1.6 m/s, respectively). Similarly, we found improvements in BDI (0.73 points) and in several Scl-90 subscales. Serum BDNF was not different between CONT and HT and did not change for therapy. <br><br>CONCLUSIONS: Our results indicate that initiation of currently recommended antihypertensive medications in newly diagnosed patients may have a significant impact on psychological well-being of patients and could influence quality of life as well.<p />  <p>Language: en</p>
LA  - en
SN  - 1419-8711
UR  - http://dx.doi.org/
ID  - ref1
ER  -