TY  - JOUR
PY  - 2017//
TI  - Biology of falls: preliminary cohort study suggesting a possible role for oxidative stress
JO  - Journal of the American Geriatrics Society
A1  - Verghese, Joe
A1  - Ayers, Emmeline
SP  - 1306
EP  - 1309
VL  - 65
IS  - 6
N2  - BACKGROUND: Biological underpinnings of falls in older adults are not well established. <br><br>OBJECTIVES: To examine the validity of selected oxidative stress and inflammatory biomarkers for predicting incident falls in community-dwelling older adults. <br><br>DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: 266 non-demented and ambulatory community-dwelling older adults (mean age 78 years, 55% women). MEASUREMENTS: Oxidative stress (malondialdehyde) and inflammatory (interleukin-6 [IL-6]) biomarkers were selected based on associations with fall risk factors, and values were log-transformed to account for non-normal distributions. <br><br>RESULTS: Over a mean follow-up of 20.5 ± 10.1 months, 119 participants fell. In Cox proportional hazards models, each one standard deviation increase in baseline log-malondialdehyde levels predicted incident falls (Hazard ratio (HR) adjusted for age, gender, education, comorbidity count, medications, log-IL-6 levels, prior falls, depressive symptoms, cognitive status, gait velocity, and balance 1.53, 95% CI 1.11-2.16). Log-IL-6 levels were not associated with falls. Participants in the highest log-malondialdehyde quartile at baseline had increased risk for incident falls than those in the lowest quartile (HR 2.47, 95% CI 1.41-4.34). <br><br>CONCLUSION: Oxidative stress predicted falls in a community-based cohort, and should be further examined as a fall risk biomarker as well as a potential target to prevent falls.<br><br>© 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society.<p />  <p>Language: en</p>
LA  - en
SN  - 0002-8614
UR  - http://dx.doi.org/10.1111/jgs.14822
ID  - ref1
ER  -