TY  - JOUR
PY  - 2017//
TI  - Inattention and reaction time variability are linked to ventromedial prefrontal volume in adolescents
JO  - Biological psychiatry
A1  - Albaugh, Matthew D.
A1  - Orr, Catherine
A1  - Chaarani, Bader
A1  - Althoff, Robert R.
A1  - Allgaier, Nicholas
A1  - D'Alberto, Nicholas
A1  - Hudson, Kelsey
A1  - Mackey, Scott
A1  - Spechler, Philip A.
A1  - Banaschewski, Tobias
A1  - Brühl, Rüdiger
A1  - Bokde, Arun L. W.
A1  - Bromberg, Uli
A1  - Büchel, Christian
A1  - Cattrell, Anna
A1  - Conrod, Patricia J.
A1  - Desrivieres, Sylvane
A1  - Flor, Herta
A1  - Frouin, Vincent
A1  - Gallinat, Jürgen
A1  - Goodman, Robert
A1  - Gowland, Penny
A1  - Grimmer, Yvonne
A1  - Heinz, Andreas
A1  - Kappel, Viola
A1  - Martinot, Jean-Luc
A1  - Paillère Martinot, Marie-Laure
A1  - Nees, Frauke
A1  - Orfanos, Dimitri Papadopoulos
A1  - Penttilä, Jani
A1  - Poustka, Luise
A1  - Paus, Tomas
A1  - Smolka, Michael N.
A1  - Struve, Maren
A1  - Walter, Henrik
A1  - Whelan, Robert
A1  - Schumann, Gunter
A1  - Garavan, Hugh
A1  - Potter, Alexandra S.
SP  - 660
EP  - 668
VL  - 82
IS  - 9
N2  - BACKGROUND: Neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have most commonly reported volumetric abnormalities in the basal ganglia, cerebellum, and prefrontal cortices. Few studies have examined the relationship between ADHD symptomatology and brain structure in population-based samples. We investigated the relationship between dimensional measures of ADHD symptomatology, brain structure, and reaction time variability-an index of lapses in attention. We also tested for associations between brain structural correlates of ADHD symptomatology and maps of dopaminergic gene expression. <br><br>METHODS: Psychopathology and imaging data were available for 1538 youths. Parent ratings of ADHD symptoms were obtained using the Development and Well-Being Assessment and the Strengths and Difficulties Questionnaire (SDQ). Self-reports of ADHD symptoms were assessed using the youth version of the SDQ. Reaction time variability was available in a subset of participants. For each measure, whole-brain voxelwise regressions with gray matter volume were calculated. <br><br>RESULTS: Parent ratings of ADHD symptoms (Development and Well-Being Assessment and SDQ), adolescent self-reports of ADHD symptoms on the SDQ, and reaction time variability were each negatively associated with gray matter volume in an overlapping region of the ventromedial prefrontal cortex. Maps of DRD1 and DRD2 gene expression were associated with brain structural correlates of ADHD symptomatology. <br><br>CONCLUSIONS: This is the first study to reveal relationships between ventromedial prefrontal cortex structure and multi-informant measures of ADHD symptoms in a large population-based sample of adolescents. Our results indicate that ventromedial prefrontal cortex structure is a biomarker for ADHD symptomatology. These findings extend previous research implicating the default mode network and dopaminergic dysfunction in ADHD.<br><br>Copyright © 2017 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0006-3223
UR  - http://dx.doi.org/10.1016/j.biopsych.2017.01.003
ID  - ref1
ER  -