TY  - JOUR
PY  - 2017//
TI  - Systematic review of genetic risk factors for sustaining a mild traumatic brain injury
JO  - Journal of neurotrauma
A1  - Panenka, William
A1  - Gardner, Andrew
A1  - Dretsch, Michael
A1  - Crynen, Gogce
A1  - Crawford, Fiona C.
A1  - Iverson, Grant L.
SP  - 2093
EP  - 2099
VL  - 34
IS  - 13
N2  - INTRODUCTION: This systematic review examined the association between genetics and risk for sustaining a traumatic brain injury. <br><br>METHODS: Articles published in English from 1980 to July 2016 obtained from the online databases PubMed, PsycINFO®, MEDLINE®, EMBASE, and Web of Science. <br><br>RESULTS: 5,903 articles were identified, 77 underwent full-text screening, and six were included in this review. Five studies examined the risk of concussion associated with Apolipoprotein E alleles (APOE-ε2 ,ε3 ,ε4,), and polymorphisms of the APOE promoter (rs405509), Brain Derived Neurotrophic Factor (BDNF, rs6265), and Dopamine Receptor D2 (DRD2, rs1800497) were each considered in two studies. Microtubule Associated Protein Tau [TAU exon 6 polymorphisms His47Tyr (rs2258689) and Ser53Pro (rs10445337)], and Neurofilament Heavy (NEHF, rs165602) genotypic variants, were the focus of single studies. No study showed an increased risk associated solely with the presence of the APOE-ε4 allele, nor were there any significant findings for the NEFH, TAU, or DRD2 genotypic variants. Two studies examined the APOE promoter -219G/T polymorphism in athletes, and both found an association with concussion. Both BDNF studies also found a significant association with concussion incidence; U.S. soldiers with the Met/Met genotype were more likely to report a history of concussion prior to deployment and to sustain a concussion during deployment. <br><br>DISCUSSION: The APOE promoter -219 G/T polymorphism and the BDNF Met/Met genotype might confer risk for sustaining a TBI. Based on research to date, the APOE-ε4 allele does not appear to influence risk. More research is needed to determine if these findings replicate.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2016.4833
ID  - ref1
ER  -