TY - JOUR
PY - 2016//
TI - Characterization of brain blood flow and the amplitude of low-frequency fluctuations in major depressive disorder: a multimodal meta-analysis
JO - Journal of affective disorders
A1 - Li, Wenbin
A1 - Chen, Ziqi
A1 - Wu, Min
A1 - Zhu, Hongyan
A1 - Gu, Lei
A1 - Zhao, Youjin
A1 - Kuang, Weihong
A1 - Bi, Feng
A1 - Kemp, Graham J.
A1 - Gong, Qiyong
SP - 303
EP - 311
VL - 210
IS -
N2 - BACKGROUND: In healthy subjects, there is an association between amplitude of low-frequency fluctuations (ALFF) and regional cerebral blood flow (rCBF). To date, no published meta-analysis has investigated changes in the regional ALFF in medication-free depressed patients.
METHODS: In this study, we aimed to explore whether resting-state rCBF and ALFF changes co-occur in the depressed brain without the potential confound of medication. Using signed differential mapping (SDM), we conducted two meta-analyses, one of rCBF studies and one of ALFF studies, involving medication-free patients with major depressive disorder (MDD). In addition, we conducted a multimodal meta-analysis to identify brain regions that showed abnormalities in both rCBF and ALFF.
RESULTS: A total of 16 studies were included in this series. We identified abnormalities in resting-state rCBF and ALFF in the left insula in medication-free MDD patients compared with healthy controls (HC). In addition, we observed altered resting-state rCBF in the limbic-subcortical-cortical circuit and altered ALFF in the default mode network (DMN) and some motor-related brain regions. LIMITATIONS: The analysis techniques, patient characteristics and clinical variables of the included studies were heterogeneous.
CONCLUSIONS: The conjoint alterations in ALFF and rCBF in the left insula may represent core neuropathological changes in medication-free patients with MDD and merit further studying.
Copyright © 2017 Elsevier B.V. All rights reserved. Language: en
LA - en
SN - 0165-0327
UR - http://dx.doi.org/10.1016/j.jad.2016.12.032
ID - ref1
ER -