TY  - JOUR
PY  - 2016//
TI  - Early-stage hyperoxia is associated with favorable neurological outcomes and survival following severe traumatic brain injury: a post-hoc analysis of the B-HYPO study
JO  - Journal of neurotrauma
A1  - Fujita, Motoki
A1  - Oda, Yasutaka
A1  - Yamashita, Susumu
A1  - Kaneda, Kotaro
A1  - Kaneko, Tadashi
A1  - Suehiro, Eiichi
A1  - Dohi, Kenji
A1  - Kuroda, Yasuhiro
A1  - Kobata, Hitoshi
A1  - Tsuruta, Ryosuke
A1  - Maekawa, Tsuyoshi
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - The effects of hyperoxia on the neurological outcomes of patients with severe traumatic brain injury (TBI) are still controversial. We examined whether the partial pressure of arterial oxygen (PaO2) and hyperoxia are associated with neurological outcomes and survival by conducting post hoc analyses of the Brain Hypothermia (B-HYPO) study, a multicenter randomized controlled trial of mild therapeutic hypothermia for severe TBI. The differences in PaO2 and PaO2/fraction of inspiratory oxygen (P/F) ratio on the first day of admission were compared between patients with favorable (n = 64) and unfavorable neurological outcomes (n = 65) and between survivors (n = 90) and deceased patients (n = 39). PaO2 and the P/F ratio were significantly greater in patients with favorable outcomes than in patients with unfavorable neurological outcomes (PaO2: 252 ± 122 vs 202 ± 87 mmHg, respectively, P = 0.008; P/F ratio: 455 ± 171 vs 389 ± 155, respectively, P = 0.022) and in survivors than in deceased patients (PaO2: 242 ± 117 vs 193 ± 75 mmHg, respectively, P = 0.005; P/F ratio: 445 ± 171 vs 370 ± 141, respectively, P = 0.018). Similar tendencies were observed in subgroup analyses in patients with fever control and therapeutic hypothermia, and in patients with an evacuated mass or other lesions (non-evacuated lesions). PaO2 was independently associated with survival (odds ratio 1.008, P = 0.037). These results suggested that early-stage hyperoxia might be associated with favorable neurological outcomes and survival following severe TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2016.4753
ID  - ref1
ER  -