TY  - JOUR
PY  - 2016//
TI  - Prevalence of incomplete functional and symptomatic recovery among patients with Head Injury but BRain Injury Debatable (HIBRID).
JO  - Journal of neurotrauma
A1  - Korley, Frederick Kofi
A1  - Diaz-Arrastia, Ramon
A1  - Falk, Hayley J.
A1  - Peters, Matthew E.
A1  - Leoutsakos, Jeannie-Marie S.
A1  - Roy, Durga
A1  - Rao, Vani
A1  - Sair, Haris I.
A1  - Ofoche, Uju
A1  - Hall, Anna J.
A1  - Akbari, Freshta
A1  - Van Meter, Timothy E.
A1  - Everett, Allen D.
A1  - Van Eyk, Jennifer
A1  - Bechtold, Kathleen T.
SP  - 1531
EP  - 1538
VL  - 34
IS  - 8
N2  - Head injury patients not meeting the American Congress of Rehabilitation Medicine (ACRM)'s criteria for mild traumatic brain injury (mTBI), referred to hereafter as HIBRID (Head Injury BRain Injury Debatable) are often excluded from studies. The prognostic importance of HIBRID is unclear. We investigated the differences in functional and symptomatic recovery at one month after injury among TBI patients classified as: HIBRID, ACRM+ cranial CT-, and cranial CT+; and trauma and healthy controls. Subjects were enrolled in an ongoing prospective cohort (Head Injury Serum Markers for Assessing Response to Trauma, HeadSMART). Outcomes measured at one month post-injury include: incomplete functional recovery (Glasgow Outcome Scale Extended<8); moderate/severe post-concussive symptoms (PCS), defined according to the ICD-10 definition; and moderate/severe depressive symptoms (Patient Health Questionnaire 9 (PHQ9)>10). Between April 2014 and May 2016, 500 TBI and 100 control subjects were enrolled and 376 TBI and 78 control subjects completed outcome assessment. The HIBRID group, constituting 23.9% of study population, had a lower incidence of incomplete functional recovery (36.7% [33/90]) than ACRM+,CT- (60.7% [125/206], p<0.01) and CT+ (78.8% [63/80], p<0.01) groups. However, the incidence of delayed functional recovery within the HIBRID group was higher than in trauma (9.3% [5/54], p<0.01) and healthy controls (0% [0/24], p<0.01). Compared to trauma/healthy controls, the HIBRID group had a higher incidence of moderate/severe depressive symptoms and a similar incidence of moderate/severe PCS. Subjects in the HIBRID group are at high risk for adverse outcomes following head injury and warrant further investigation.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2016.4723
ID  - ref1
ER  -