TY  - JOUR
PY  - 2016//
TI  - A clinically relevant closed-head model of single and repeat concussive injury in the adult rat using a controlled cortical impact device
JO  - Journal of neurotrauma
A1  - Jamnia, Naseem
A1  - Urban, Janice H.
A1  - Stuzmann, Grace Beth
A1  - Chiren, Sarah
A1  - Reisenbigler, Emily
A1  - Marr, Robert
A1  - Peterson, Daniel A.
A1  - Kozlowski, Dorothy A.
SP  - 1351
EP  - 1363
VL  - 34
IS  - 7
N2  - Repeat concussions (RC) can result in significant long-term neurological consequences and increased risk for neurodegenerative disease compared to single concussion (SC). Mechanisms underlying this difference are poorly understood and best elucidated using an animal model. To the best of our knowledge, there is no closed-head model in the adult rat using a commercially available device. We developed a novel and clinically relevant closed-head injury (CHI) model of both single and multiple concussions in the adult rat using a controlled cortical impact (CCI) device. Adult rats received either a single or repeat CHI (3 injuries, 48h apart) and acute deficits in sensorimotor and locomotor function (foot fault; open field), memory (novel object), and anxiety (open field; corticosterone) were measured. Assessment of cellular pathology was also conducted. Within the first week post-CHI, rats with single or repeat concussions showed similar deficits in motor coordination, decreased locomotion, and higher resting corticosterone levels. Rats with a single concussion had memory deficits post injury day (PID) 3 that recovered to sham levels by PID 7; however, rats with repeat concussions continued to show memory deficits. No obvious gross pathology was observed on the cortical surface or in coronal sections. Further examination showed thinning of the cortex and corpus callosum in RC animals compared to shams and increased axonal pathology in the corpus callosum of both SC and RC animals. Our data present a model of CHI that results in clinically relevant markers of concussion and an early differentiation between single and repeat concussions.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2016.4517
ID  - ref1
ER  -