TY  - JOUR
PY  - 2016//
TI  - Cerium oxide nanoparticles improve outcome after in vitro and in vivo mild traumatic brain injury
JO  - Journal of neurotrauma
A1  - Bailey, Zachary S.
A1  - Nilson, Eric
A1  - Bates, John
A1  - Oyalowo, Adewole
A1  - Hockey, Kevin S.
A1  - Sajja, Sujith
A1  - Thorpe, Chevon
A1  - Rogers, Heidi
A1  - Dunn, Bryce
A1  - Frey, Aaron S.
A1  - Billings, Marc J.
A1  - Sholar, Christopher A.
A1  - Hermundstad, Amy
A1  - Kumar, Challa
A1  - Vandevord, Pamela J.
A1  - Rzigalinski, Beverly A.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Mild traumatic brain injury results in aberrant free radical generation, which is associated with oxidative stress, secondary injury signaling cascades, mitochondrial dysfunction, and poor functional outcome. Pharmacological targeting of free radicals with antioxidants has been examined as an approach for treatment, but has met with limited success. Conventional antioxidants currently available scavenge a single free radical, before they are destroyed in the process. Here, we report for the first time, that a novel regenerative cerium oxide nanoparticle antioxidant reduces neuronal death and calcium dysregulation after in vitro trauma. Further, using an in vivo model of mild fluid percussion brain injury in the rat, we report that cerium oxide nanoparticles also preserve endogenous antioxidant systems, decrease macromolecular free radical damage, and improve cognitive function. Taken together, our results demonstrate that cerium oxide nanoparticles are a novel nanopharmaceutical with potential for mitigating neuropathological effects of mild traumatic brain injury and modifying the course of recovery.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2016.4644
ID  - ref1
ER  -