TY  - JOUR
PY  - 2016//
TI  - Mild traumatic brain injury produces long-lasting deficits in synaptic plasticity in the female juvenile hippocampus
JO  - Journal of neurotrauma
A1  - White, Emily
A1  - Pinar, Cristina
A1  - Bostrom, Crystal
A1  - Meconi, Alicia
A1  - Christie, Brian Ross
SP  - 1111
EP  - 1123
VL  - 34
IS  - 5
N2  - Mild traumatic brain injury (mTBI) is becoming recognized as a significant concern in modern society. In particular, juveniles are being increasingly seen as a vulnerable time period for mTBI, as this is the final developmental period for the brain and typically involves robust synaptic reorganization and axonal myelination. Another issue that is being hotly debated is whether mTBI differentially impacts the male and female brain. To examine the impact of mTBI in the juvenile brain, we measured hippocampal synaptic plasticity using a closed-head mTBI model in male and female Long-Evans rats (25-28 days of age) at either one hour, one day, seven days, or 28 days post-injury. In female rats, the DG region ipsilateral to the impact showed a significant reduction in long-term potentiation (LTP) at one day which persisted to 28 days following injury. In male rats, the deficit in LTP was maximal in the CA1 and DG subfields ipsilateral to the impact site at seven days post-injury, but these deficits did not persist to 28 days post-injury. These data indicate that mTBI can produce more immediate and persistent impairments in synaptic plasticity in the female brain.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2016.4638
ID  - ref1
ER  -