TY  - JOUR
PY  - 2016//
TI  - Sarcopenic obesity and its temporal associations with changes in bone mineral density, incident falls and fractures in older men: the concord health and ageing in men project
JO  - Journal of bone and mineral research
A1  - Scott, David
A1  - Seibel, Markus
A1  - Cumming, Robert
A1  - Naganathan, Vasi
A1  - Blyth, Fiona
A1  - Le Couteur, David G.
A1  - Handelsman, David J.
A1  - Waite, Louise M.
A1  - Hirani, Vasant
SP  - 575
EP  - 583
VL  - 32
IS  - 3
N2  - Body composition and muscle function have important implications for falls and fractures in older adults. We aimed to investigate longitudinal associations between sarcopenic obesity and its components with bone mineral density (BMD), and incident falls and fractures, in Australian community-dwelling older men. 1,486 men aged ≥70 years from the Concord Health and Ageing in Men Project (CHAMP) study were assessed at baseline (2005-2007), 2 year follow-up (2007-2009; N = 1,238), and 5 year follow-up (2010-2013; N = 861). At all three time-points measurements included appendicular lean mass [ALM], body fat percentage and total hip BMD, hand grip strength and gait speed. Participants were contacted every 4 months for 6.1 ± 2.1 years to ascertain incident falls and fractures, the latter being confirmed by radiographic reports. Sarcopenic obesity was defined using sarcopenia algorithms of the European Working Group on Sarcopenia (EWGSOP) and the Foundation for the National Institutes of Health (FNIH), and total body fat ≥30% of total mass. Sarcopenic obese men did not have significantly different total hip BMD over five years compared with non-sarcopenic non-obese men (P > 0.05). EWGSOP-defined sarcopenic obesity at baseline was associated with significantly higher two-year falls rates (incidence rate ratio: 1.66; 95% CI: 1.16, 2.37), as were non-sarcopenic obesity (1.30; 1.04, 1.62) and sarcopenic non-obesity (1.58; 1.14, 2.17), compared with non-sarcopenic non-obese. No association with falls was found for sarcopenic obesity using the FNIH definition (1.01; 0.63, 1.60), but after multivariable adjustment the FNIH-defined non-sarcopenic obese group had a reduced hazard for any six-year fracture compared with sarcopenic obese men (hazard ratio: 0.44; 95% CI: 0.23, 0.86). In older men, EWGSOP-defined sarcopenic obesity is associated with increased falls rates over two years, and FNIH-defined sarcopenic obese men have increased fracture risk over six years, compared with non-sarcopenic obese men. This article is protected by copyright. All rights reserved.<br><br>This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0884-0431
UR  - http://dx.doi.org/10.1002/jbmr.3016
ID  - ref1
ER  -