TY  - JOUR
PY  - 2016//
TI  - Do atypical antipsychotics have antisuicidal effects? A hypothesis-generating overview
JO  - International journal of molecular sciences
A1  - Pompili, Maurizio
A1  - Baldessarini, Ross J.
A1  - Forte, Alberto
A1  - Erbuto, Denise
A1  - Serafini, Gianluca
A1  - Fiorillo, Andrea
A1  - Amore, Mario
A1  - Girardi, Paolo
SP  - e17101700
EP  - e17101700
VL  - 17
IS  - 10
N2  - Modern antipsychotic drugs are employed increasingly in the treatment of mood disorders as well as psychoses, stimulating interest in their possible contributions to altering suicidal risk. Clozapine remains the only treatment with an FDA-recognized indication for reducing suicidal risk (in schizophrenia). We carried out a systematic, computerized search for reports of studies involving antipsychotic drug treatment and suicidal behaviors. A total of 19 reports provide data with preliminary support for potential suicide risk-reducing effects of olanzapine, quetiapine, ziprasidone, aripiprazole, and asenapine in addition to clozapine, and provide some support for antipsychotic drug treatment in general. These preliminary findings encourage further testing of antipsychotics for effects on suicidal behavior, making use of explicit, pre-planned assessments of suicidal behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 1661-6596
UR  - http://dx.doi.org/10.3390/ijms17101700
ID  - ref1
ER  -