TY  - JOUR
PY  - 2016//
TI  - Surface enhanced raman scattering and gated materials for sensing applications: the ultrasensitive detection of mycoplasma and cocaine
JO  - Chemistry: a European journal
A1  - Oroval, Mar
A1  - Coronado-Puchau, Marc
A1  - Langer, Judith
A1  - Sanz-Ortiz, Marta Norah
A1  - Ribes, Ángela
A1  - Aznar, Elena
A1  - Coll, Carmen
A1  - Marcos, María Dolores
A1  - Sancenón, Félix
A1  - Liz-Marzán, Luis M.
A1  - Martínez-Máñez, Ramón
SP  - 13488
EP  - 13495
VL  - 22
IS  - 38
N2  - We present herein a novel combination of gated mesoporous silica nanoparticles (MSNs) and surface-enhanced Raman scattering (SERS) for sensing applications. As a proof-of-concept, we show the design of a system comprising MSNs loaded with crystal violet (CV), a molecule with high Raman cross section acting as SERS reporter, and capped with either a suitable DNA sequence for the detection of Mycoplasma genomic DNA or with an aptamer that selectively coordinates cocaine. In both cases the presence of the corresponding target analyte in solution (i.e., genomic DNA or cocaine) resulted in the release of CV. CV delivery was detected by SERS upon adsorption on gold nanotriangles (AuNTs), which display an efficient electromagnetic field enhancement and a high colloidal stability. By using this novel procedure a limit of detection of at least 30 copies DNA per μL was determined for the detection of Mycoplasma genomic DNA, whereas cocaine was detected at concentrations as low as 10 nm.<p />  <p>Language: en</p>
LA  - en
SN  - 0947-6539
UR  - http://dx.doi.org/10.1002/chem.201602457
ID  - ref1
ER  -