TY  - JOUR
PY  - 2016//
TI  - The healing effect of Pistacia lentiscus fruit oil on laser burn
JO  - Pharmaceutical biology
A1  - Khedir, Sameh Ben
A1  - Bardaa, Sana
A1  - Chabchoub, Naourez
A1  - Moalla, Dorsaf
A1  - Sahnoun, Zouheir
A1  - Rebai, Tarek
SP  - 1407
EP  - 1414
VL  - 55
IS  - 1
N2  - CONTEXT: Since antiquity, Pistacia lentiscus L. (Anacardiaceae) fruit oil (PLFO) has been used as a remedy for primary health care such as burn treatment. <br><br>OBJECTIVE: This study assesses the healing effect of PLFO on CO2 laser fractional burn in a rat model. <br><br>MATERIALS AND METHODS: The study was carried out on 18 adult male Wistar rats. A second-degree laser burn (wound area = 2.2 cm(2)) was inflicted in the dorsal region by the application of CO2 fractional laser within the following parameters; Energy level: 25 MJ and Depth level: 4. After applying laser, the rats were divided into three groups: the first was treated with saline solution, the second with a reference cream 'CYTOL BASIC(®)' (0.13 μg/mm(2)) and the third with PLFO (0.52 μL/mm(2)). All treatments were topically administered for eight days. The healing effect was assessed using macroscopic, histological and biochemical parameters. <br><br>RESULTS: After eight days, the higher percentage of wound healing contraction was observed among the PLFO-treated group (100%) followed by the 'CYTOL BASIC(®)' treated group (61.36%) and untreated group (32.27%). During the treatment, the PLFO-treated group showed less erythema, less crusting/scabbing, higher general wound appearance scores and a high content of collagen (220.67 ± 7.48 mg/g of tissue) than the other groups. <br><br>DISCUSSION AND CONCLUSION: The current study has shown, for the first time, the healing effect of PLFO on CO2 laser fractional burn. Their wound healing effect could be attributed to their antimicrobial, anti-inflammatory and antioxidant effects.<p />  <p>Language: en</p>
LA  - en
SN  - 1388-0209
UR  - http://dx.doi.org/10.1080/13880209.2016.1233569
ID  - ref1
ER  -