TY - JOUR
PY - 2016//
TI - A longitudinal study of adolescent psychotic experiences and later development of substance use disorder and suicidal behavior
JO - Schizophrenia Research
A1 - Cederlöf, Martin
A1 - Kuja-Halkola, Ralf
A1 - Larsson, Henrik
A1 - Sjölander, Arvid
A1 - Östberg, Per
A1 - Lundström, Sebastian
A1 - Kelleher, Ian
A1 - Lichtenstein, Paul
SP - 13
EP - 16
VL - 181
IS -
N2 - INTRODUCTION: Psychotic experiences are associated with later substance use disorder and suicidal behavior, but individual psychotic experiences have not been examined in a longitudinal data set. Also, the potential dose-response relationship between these phenomena remains unknown.
METHOD: Cohort study including 9242 adolescents who participated in The Child and Adolescent Twin Study in Sweden (CATSS). At ages 15 and/or 18, seven psychotic experiences (auditory and visual hallucinations, and five delusions) were assessed via questionnaires. Outcomes at follow-up were physician-assigned diagnoses of substance use disorder and suicide attempts ascertained from the Swedish Patient Register. Associations were estimated with Cox regressions and expressed as hazard ratios.
RESULTS: All psychotic experiences were associated with later substance use disorder and/or suicide attempts, with hazard ratios ranging from 1.6 to 3.0. A dose-response relationship was observed between psychotic experiences and later substance use disorder, and suicide attempt.
DISCUSSION: Auditory and visual hallucinations as well as delusions in adolescence are associated with later development of substance use disorder and suicide attempt, and there is a dose-response relationship between the load of psychotic experiences and these adverse outcomes. Clinicians should assess subclinical hallucinations as well as delusions in psychiatric evaluations of adolescents.
Copyright © 2016 Elsevier B.V. All rights reserved. Language: en
LA - en
SN - 0920-9964
UR - http://dx.doi.org/10.1016/j.schres.2016.08.029
ID - ref1
ER -