TY  - JOUR
PY  - 2016//
TI  - The association of genetic predisposition to depressive symptoms with non-suicidal and suicidal self-injuries
JO  - Behavior genetics
A1  - Maciejewski, Dominique F.
A1  - Renteria, Miguel E.
A1  - Abdellaoui, Abdel
A1  - Medland, Sarah E.
A1  - Few, Lauren R.
A1  - Gordon, Scott D.
A1  - Madden, Pamela A. F.
A1  - Montgomery, Grant
A1  - Trull, Timothy J.
A1  - Heath, Andrew C.
A1  - Statham, Dixie J.
A1  - Martin, Nicholas G.
A1  - Zietsch, Brendan P.
A1  - Verweij, Karin J. H.
SP  - 3
EP  - 10
VL  - 47
IS  - 1
N2  - Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 %) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 %). Polygenic risk scores did not significantly predict NSSI. <br><br>RESULTS highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI.<p />  <p>Language: en</p>
LA  - en
SN  - 0001-8244
UR  - http://dx.doi.org/10.1007/s10519-016-9809-z
ID  - ref1
ER  -