TY  - JOUR
PY  - 2016//
TI  - Controlled fire use in early humans might have triggered the evolutionary emergence of tuberculosis
JO  - Proceedings of the National Academy of Sciences of the United States of America
A1  - Chisholm, Rebecca H.
A1  - Trauer, James M.
A1  - Curnoe, Darren
A1  - Tanaka, Mark M.
SP  - 9051
EP  - 9056
VL  - 113
IS  - 32
N2  - Tuberculosis (TB) is caused by the Mycobacterium tuberculosis complex (MTBC), a wildly successful group of organisms and the leading cause of death resulting from a single bacterial pathogen worldwide. It is generally accepted that MTBC established itself in human populations in Africa and that animal-infecting strains diverged from human strains. However, the precise causal factors of TB emergence remain unknown. Here, we propose that the advent of controlled fire use in early humans created the ideal conditions for the emergence of TB as a transmissible disease. This hypothesis is supported by mathematical modeling together with a synthesis of evidence from epidemiology, evolutionary genetics, and paleoanthropology.<p />  <p>Language: en</p>
LA  - en
SN  - 0027-8424
UR  - http://dx.doi.org/10.1073/pnas.1603224113
ID  - ref1
ER  -