TY  - JOUR
PY  - 2016//
TI  - Single dose oral toxicity study of Picrorhiza kurroa rhizome extract in Wistar rats
JO  - Fundamental toxicological sciences
A1  - Krishna, Acharya Bal
A1  - Manikyam, Hemanth Kumar
A1  - Sharma, Vinay K.
A1  - Sharma, Niti
SP  - 9
EP  - 12
VL  - 3
IS  - 1
N2  - Picrorhiza kurroa is a well-known ayurvedic or herbal medicine which is used very commonly in the treatment of various diseases. Therefore, we studied the oral toxicity of Picrorhiza kurroa rhizome extract in rats. A single high dose of the extract at 2000 mg/kg body weight was tested on Wistar rats. Mortality/viability and clinical signs were recorded on test day 0 (prior to administration), 7, 14 and at death. All animals appeared normal from day one to throughout the experimental procedure. Picrorhiza kurroa rhizome extract is non-toxic to rats and helped in weight gain with LD50 > 2000 mg/kg body weight. Oral administration of Picrorhiza kurroa is not connected with any toxicologically significant effects and the data could provide satisfactory preclinical evidence of safety to launch a clinical trial on a standardized formulation of the plant extracts.<p />  <p>Language: en</p>
LA  - en
SN  - 2189-115X
UR  - http://dx.doi.org/10.2131/fts.3.9
ID  - ref1
ER  -