TY  - JOUR
PY  - 2016//
TI  - Correlation between expression of peripheral IL-17 protein and aggression of bipolar mania
JO  - Fa Yi Xue Za Zhi
A1  - Li, Hao-zhe
A1  - Hong, Wu
A1  - Wang, Zuo-wei
A1  - Yuan, Cheng-mei
A1  - Li, Ze-zhi
A1  - Huang, Jia
A1  - Zhang, Chen
A1  - Li, Ning-ning
A1  - Lin, Zhi-guang
A1  - Fang, Yi-Ru
SP  - 40
EP  - 44
VL  - 32
IS  - 1
N2  - OBJECTIVE: To explore the correlation between the interleukin-17 (IL-17) level of peripheral blood and aggression of bipolar mania. <br><br>METHODS: Thirty-six patients of bipolar mania were selected as experimental group by DSM-IV-TR and received treatment with quetiapine and lithium. Thirty-six healthy volunteers with similar age and gender were selected as control group. The level of IL-17 at baseline in each group and the level of IL-17 in the experimental group after treatment for 2, 4 and 8 weeks were detected by ELISA. <br><br>RESULTS: The level of IL-17 in experimental group at baseline, after treatment for 2 and 4 weeks were all significantly higher than that in control group. After 8 weeks treatment, there was no significant difference between the two groups (P > 0.05). After 2, 4 and 8 weeks treatment, the total score and aggression score of Young Mania Rating Score (YMRS) were significantly lower than the baseline level (P < 0.05). In experimental group, the level of IL-17 was positively correlated with the two scores of YMRS at baseline (P < 0.05). <br><br>CONCLUSION: Bipolar mania may be related to the up-regulation of IL-17. The level of IL-17 is related to the severity of manic symptoms at baseline, especially aggression symptom.<p />  <p>Language: zh</p>
LA  - zh
SN  - 1004-5619
UR  - http://dx.doi.org/
ID  - ref1
ER  -