TY  - JOUR
PY  - 2016//
TI  - Over-the-counter drug induced autoimmune hepatitis
JO  - Internal medicine
A1  - Takeda, Karin
A1  - Oda, Masaya
A1  - Okada, Takemichi
A1  - Yamazaki, Hitoshi
A1  - Ohbu, Makoto
A1  - Watanabe, Masaaki
A1  - Yokomori, Hiroaki
SP  - 1293
EP  - 1297
VL  - 55
IS  - 10
N2  - A 64-year-old man seeking treatment for a common cold was admitted to our hospital due to symptoms of general fatigue and liver dysfunction. A thorough history review revealed that the patient had recently started taking an over-the-counter (OTC) drug. Drug-induced lymphocyte stimulation tests were positive. Serum markers for autoimmune hepatitis (AIH) were particularly elevated. Liver biopsy revealed spotty necrosis and ceroid-pigmented Kupffer cells and piecemeal necrosis with multiple plasma cells. He responded to corticosteroids, thus suggesting the presence of an immune-mediated component associated with the liver injury. Liver injury after using OTCs should be included in the differential diagnosis for chronic hepatitis with features of AIH.<p />  <p>Language: en</p>
LA  - en
SN  - 0918-2918
UR  - http://dx.doi.org/10.2169/internalmedicine.55.5509
ID  - ref1
ER  -