TY  - JOUR
PY  - 2016//
TI  - Post mTBI fatigue is associated with abnormal brain functional connectivity
JO  - Scientific reports
A1  - Nordin, Love Engström
A1  - Möller, Marika Christina
A1  - Julin, Per
A1  - Bartfai, Aniko
A1  - Hashim, Farouk
A1  - Li, Tie-Qiang
SP  - 21183
EP  - 21183
VL  - 6
IS  - 1
N2  - This study set out to investigate the behavioral correlates of changes in resting-state functional connectivity before and after performing a 20 minute continuous psychomotor vigilance task (PVT) for patients with chronic post-concussion syndrome. Ten patients in chronic phase after mild traumatic brain injury (mTBI) with persisting symptoms of fatigue and ten matched healthy controls participated in the study. We assessed the participants' fatigue levels and conducted resting-state fMRI before and after a sustained PVT. We evaluated the changes in brain functional connectivity indices in relation to the subject's fatigue behavior using a quantitative data-driven analysis approach. We found that the PVT invoked significant mental fatigue and specific functional connectivity changes in mTBI patients. Furthermore, we found a significant linear correlation between self-reported fatigue and functional connectivity in the thalamus and middle frontal cortex. Our findings indicate that resting-state fMRI measurements may be a useful indicator of performance potential and a marker of fatigue level in the neural attentional system.<p />  <p>Language: en</p>
LA  - en
SN  - 2045-2322
UR  - http://dx.doi.org/10.1038/srep21183
ID  - ref1
ER  -