TY  - JOUR
PY  - 2016//
TI  - Chronic cerebrovascular dysfunction after traumatic brain injury
JO  - Journal of Neuroscience Research
A1  - Jullienne, Amandine
A1  - Obenaus, Andre
A1  - Ickova, Aleksandra
A1  - Savona-Baron, Catherine
A1  - Pearce, William J.
A1  - Badaut, Jerome
SP  - 609
EP  - 622
VL  - 94
IS  - 7
N2  - Traumatic brain injuries (TBI) often involve vascular dysfunction that leads to long-term alterations in physiological and cognitive functions of the brain. Indeed, all the cells that form blood vessels and that are involved in maintaining their proper function can be altered by TBI. This Review focuses on the different types of cerebrovascular dysfunction that occur after TBI, including cerebral blood flow alterations, autoregulation impairments, subarachnoid hemorrhage, vasospasms, blood-brain barrier disruption, and edema formation. We also discuss the mechanisms that mediate these dysfunctions, focusing on the cellular components of cerebral blood vessels (endothelial cells, smooth muscle cells, astrocytes, pericytes, perivascular nerves) and their known and potential roles in the secondary injury cascade. © 2016 Wiley Periodicals, Inc.<br><br>© 2016 Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 0360-4012
UR  - http://dx.doi.org/10.1002/jnr.23732
ID  - ref1
ER  -