TY  - JOUR
PY  - 2016//
TI  - Adverse drug reactions of systemic antihistamines in children in the Netherlands
JO  - Archives of disease in childhood
A1  - de Vries, Tjalling W.
A1  - van Hunsel, Florence
SP  - 968
EP  - 970
VL  - 101
IS  - 10
N2  - BACKGROUND: Antihistamines are used for the treatment of allergic rhinitis, allergic conjunctivitis, chronic spontaneous urticaria and atopic eczema. <br><br>OBJECTIVE: To study the reports of adverse drug reactions (ADRs) in children using antihistamines to provide prescribers with an overview of the possible toxicity. <br><br>DESIGN: We studied ADRs in children reported to the Netherlands Pharmacovigilance Centre Lareb in the years 1991-2014, assessed the Naranjo score and, when possible, computed the reporting OR. <br><br>RESULTS: Serious ADRs included one death (malignant neuroleptic syndrome), cardiac arrhythmia (one case) and convulsions (three cases). Skin eruptions, headache and somnolence were the most frequently reported ADRs. Aggression and agitation were also reported. <br><br>CONCLUSIONS: Toxicity can occur with second-generation antihistamines. The main toxicity relates to skin eruptions and central nervous system problems.<br><br>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/<p />  <p>Language: en</p>
LA  - en
SN  - 0003-9888
UR  - http://dx.doi.org/10.1136/archdischild-2015-310315
ID  - ref1
ER  -