TY  - JOUR
PY  - 2016//
TI  - Recovery curves for pediatric burn survivors: advances in patient-oriented outcomes
JO  - JAMA pediatrics
A1  - Kazis, Lewis E.
A1  - Lee, Austin F. S.
A1  - Rose, Mary
A1  - Liang, Matthew H.
A1  - Li, Nien-Chen
A1  - Ren, Xinhua S.
A1  - Sheridan, Robert
A1  - Gilroy-Lewis, Janet
A1  - Stoddard, Fred
A1  - Hinson, Michelle
A1  - Warden, Glenn
A1  - Stubbs, Kim
A1  - Blakeney, Patricia
A1  - Meyer, Walter
A1  - McCauley, Robert
A1  - Herndon, David
A1  - Palmieri, Tina
A1  - Mooney, Kate
A1  - Wood, David
A1  - Pidcock, Frank
A1  - Reilly, Debra
A1  - Cullen, Marc
A1  - Calvert, Catherine
A1  - Ryan, Colleen M.
A1  - Schneider, Jeffrey C.
A1  - Soley-Bori, Marina
A1  - Tompkins, Ronald G.
SP  - 534
EP  - 542
VL  - 170
IS  - 6
N2  - IMPORTANCE: Patient-reported outcomes serving as benchmarks for recovery of pediatric burn survivors are lacking, and new approaches using longitudinal cohorts for monitoring their expected recovery based on statistical models are needed for patient management during the early years following the burn. <br><br>OBJECTIVE: To describe multidimensional patient-reported outcomes among pediatric burn survivors younger than 5 years to establish benchmarks using recovery curve methods. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study of pediatric burn survivors younger than 5 years at 12 burn centers. Age-matched nonburned reference groups were studied to define expected results in normal growth and development. The Burn Outcomes Questionnaire for children aged 0 to 5 years (BOQ0-5) was administered to parents of children who had burns and were younger than 5 years. Mixed models were used to generate 48-month recovery curves for each of the 10 BOQ0-5 domains. The study was conducted between January 1999 and December 2008. MAIN OUTCOMES AND MEASURES: The 10 BOQ0-5 domains including play, language, fine motor skills, gross motor skills, emotional behavior, family functioning, pain/itching, appearance, satisfaction with care, and worry/concern up to 48 months after burn injury. <br><br>RESULTS: A total of 336 pediatric burn survivors younger than 5 years (mean [SD] age, 2.0 [1.2] years; 58.4% male; 60.2% white, 18.6% black, and 12.0% Hispanic) and 285 age-matched nonburned controls (mean [SD] age, 2.4 [1.3] years; 51.1% male; 67.1% white, 8.9% black, and 15.0% Hispanic) completed the study. Predicted scores improved exponentially over time for 5 of the BOQ0-5 domains (predicted scores at 1 month vs 24 months: play, 48.6 vs 52.1 [P RESULTS:  = .03]; language, 49.2 vs 54.4 [P  RESULTS: < RESULTS:  .001]; gross motor skills, 48.7 vs 53.0 [P = .002]; pain/itching, 15.8 vs 33.5 [P  RESULTS: < RESULTS:  .001]; and worry/concern, 31.6 vs 44.9 [P  RESULTS: < RESULTS:  .001]). Pediatric burn survivors had higher scores in language, emotional behavior, and family functioning domains compared with healthy children in later months. <br><br>CONCLUSIONS AND RELEVANCE: This study demonstrates significant deficits in multiple functional domains across pediatric burn survivors compared with controls. Recovery curves can be used to recognize deviation from the expected course and tailor care to patient needs.<p />  <p>Language: en</p>
LA  - en
SN  - 2168-6211
UR  - http://dx.doi.org/10.1001/jamapediatrics.2015.4722
ID  - ref1
ER  -