TY  - JOUR
PY  - 2016//
TI  - High trait aggression in men is associated with low 5-HT levels, as indexed by 5-HT4 receptor binding
JO  - Social cognitive and affective neuroscience
A1  - da Cunha-Bang, Sofi
A1  - Mc Mahon, Brenda
A1  - MacDonald Fisher, Patrick
A1  - Jensen, Peter Steen
A1  - Svarer, Claus
A1  - Moos Knudsen, Gitte
SP  - 548
EP  - 555
VL  - 11
IS  - 4
N2  - Impulsive aggression has commonly been associated with a dysfunction of the serotonin (5-HT) system: many, but not all, studies point to an inverse relationship between 5-HT and aggression. As cerebral 5-HT4 receptor (5-HT4R) binding has recently been recognized as a proxy for stable brain levels of 5-HT, we here test the hypothesis in healthy men and women that brain 5-HT levels, as indexed by cerebral 5-HT4R, are inversely correlated with trait aggression and impulsivity. Sixty-one individuals (47 men) underwent positron emission tomography scanning with the radioligand [(11)C]SB207145 for quantification of brain 5-HT4R binding. The Buss-Perry Aggression Questionnaire (BPAQ) and the Barratt Impulsiveness Scale were used for assessment of trait aggression and trait impulsivity. Among male subjects, there was a positive correlation between global 5-HT4R and BPAQ total score (P = 0.037) as well as BPAQ physical aggression (P = 0.025). No main effect of global 5-HT4R on trait aggression or impulsivity was found in the mixed gender sample, but there was evidence for sex interaction effects in the relationship between global 5-HT4R and BPAQ physical aggression. In conclusion we found that low cerebral 5-HT levels, as indexed by 5-HT4R binding were associated with high trait aggression in males, but not in females.<p />  <p>Language: en</p>
LA  - en
SN  - 1749-5016
UR  - http://dx.doi.org/10.1093/scan/nsv140
ID  - ref1
ER  -