TY  - JOUR
PY  - 2015//
TI  - Outcome after repetitive mild traumatic brain injury is temporally related to glucose uptake profile at time of second injury
JO  - Journal of neurotrauma
A1  - Selwyn, Reed G.
A1  - Cooney, Sean J.
A1  - Khayrullina, Guzal
A1  - Hokenbury, Nicole
A1  - Wilson, Colin M.
A1  - Jaiswal, Shalini
A1  - Bermudez, Sara
A1  - Armstrong, Regina C.
A1  - Byrnes, Kimberly
SP  - 1479
EP  - 1491
VL  - 33
IS  - 16
N2  - Repeated mild traumatic brain injury (rmTBI) results in worsened outcomes compared to a single injury, but the mechanism of this phenomenon is unclear. We have previously shown that mild TBI in a rat lateral fluid percussion model results in globally depressed glucose uptake, with a peak depression at 24 hours that resolves by 16 days post-injury. The current study investigated the outcomes of a repeat injury conducted at various times during this period of depressed glucose uptake. Adult male rats were therefore subjected to rmTBI with a latency of 24 hours, 5 days or 15 days between injuries, followed by assessment of motor function, histopathology and glucose uptake using positron emission tomography (PET). Rats that received a 24 hour rmTBI showed significant deficits in motor function tasks as well as significant increases in lesion volume and neuronal damage. The level of microglial and astrocytic activation was also associated with the timing of the second impact. Finally, rmTBI with latencies of 24 hours and 5 days showed significant alterations in FDG uptake in comparison to baseline scans. Therefore, we conclude that the state of the metabolic environment, as indicated by FDG-PET, at the time of the repeat injury significantly influences neurological outcomes.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2015.4129
ID  - ref1
ER  -