TY  - JOUR
PY  - 2015//
TI  - Refractory status epilepticus, serious rhabdomyolysis, acute liver injury, and pancytopenia after a massive intake of ethyl methanesulfonate: a case report
JO  - International journal of clinical and experimental medicine
A1  - Yamazaki, Hiroyuki
A1  - Tajima, Shogo
A1  - Takeuchi, Takahiro
SP  - 16863
EP  - 16867
VL  - 8
IS  - 9
N2  - Ethyl methanesulfonate is a mutagenic, alkylating agent and considered harmful to humans at levels greater than a certain threshold; however, the toxicity at high doses remains unclear. We report a case of a Japanese man who presented with status epilepticus, rhabdomyolysis, pancytopenia, and hair loss after accidental ingestion of a massive amount of ethyl methanesulfonate. The patient completely recovered with critical care, including multiple antiepileptic drugs, renal replacement therapy, blood transfusion, granulocyte colony-stimulating factor therapy, and antibacterial/fungal prophylaxis. The case indicates that ethyl methanesulfonate causes neurotoxicity, hepatotoxicity, hematotoxicity, and renal toxicity, which can be successfully treated with appropriate palliative therapies.<p />  <p>Language: en</p>
LA  - en
SN  - 1940-5901
UR  - http://dx.doi.org/
ID  - ref1
ER  -