TY  - JOUR
PY  - 2015//
TI  - Pharmacological preventions of brain injury following experimental germinal matrix hemorrhage: an up-to-date review
JO  - Translational stroke research
A1  - Tang, Jun
A1  - Tao, Yihao
A1  - Jiang, Bing
A1  - Chen, Qianwei
A1  - Hua, Feng
A1  - Zhang, John
A1  - Zhu, Gang
A1  - Chen, Zhiyong
SP  - 20
EP  - 32
VL  - 7
IS  - 1
N2  - Germinal matrix hemorrhage (GMH) is defined as the rupture of immature blood vessels in the subependymal zone of premature infants with significant mortality and morbidity. Considering the notable social and ecological stress brought by GMH-induced brain injury and sequelae, safe and efficient pharmacological preventions are badly needed. Currently, several appropriate animal models are available to mimic the clinical outcomes of GMH in human patients. In the long run, hemorrhagic strokes are the research target. Previously, we found that minocycline was efficient to alleviate GMH-induced brain edema and posthemorrhagic hydrocephalus (PHH) in rats, which may be closely related to the activation of cannabinoid receptor 2 (CB2R). However, how the two molecules correlate and the underlined molecular pathway remain unknown. To extensively understand current experimental GMH treatment, this literature review critically evaluates existing therapeutic strategies, potential treatments, and potentially involved molecular mechanisms. Each strategy has its own advantages and disadvantages. Some of the mechanisms are still controversial, requiring an increasing number of animal experiments before the therapeutic strategy would be widely accepted.<p />  <p>Language: en</p>
LA  - en
SN  - 1868-4483
UR  - http://dx.doi.org/10.1007/s12975-015-0432-8
ID  - ref1
ER  -