TY  - JOUR
PY  - 2015//
TI  - Impact of Xuebijing and ulinastatin as assistance for hemoperfusion in treating acute paraquat poisoning
JO  - International journal of clinical and experimental medicine
A1  - Shi, Xiaofeng
A1  - Zhang, Yue
A1  - Wang, Yongqiang
SP  - 14018
EP  - 14023
VL  - 8
IS  - 8
N2  - OBJECTIVE: As the effect of Xuebijing as combined treatment in hemoperfusion (HP) toward acute paraquat (PQ) poisoning is not clear. We retrospectively analyzed 119 cases of acute paraquat poisoning in Tianjin first central hospital; the patients were divided into 3 groups based on treatment. Control (group A) patients underwent standard hemoperfusion with conventional treatment, while the experimental groups combined hemoperfusion with Xuebijing (group B) or ulinastatin (group C). Standard biomedical indicators, such as organ dysfunction and mortality were recorded and compiled, both in short (<7 days) and long (7-28 days) terms. Then, the effect of Xuebijing in combination to the standard (HP) treatment was evaluated by direct comparison. The results showed that using either Xuebijing or ulinastatin as additional treatment to standard HP significantly helped the overall outcomes, as evidenced by lower organ dysfunction and mortality. In addition, Xuebijing (group B) yielded a more pronounced improvement compared with ulinastatin (group C) in combination with HP (All P<0.05). Our findings indicated that both Xuebijing and ulinastatin provided positive impacts on HP treatment toward acute paraquat poisoning, with better outcomes observed with Xuebijing, which should be considered for more frequent use in clinical practice.<p />  <p>Language: en</p>
LA  - en
SN  - 1940-5901
UR  - http://dx.doi.org/
ID  - ref1
ER  -