TY  - JOUR
PY  - 2015//
TI  - Human and experimental toxicology of orellanine
JO  - Human and experimental toxicology
A1  - Dinis-Oliveira, Ricardo Jorge
A1  - Soares, Mariana
A1  - Rocha-Pereira, Carolina
A1  - Carvalho, Felix
SP  - 1016
EP  - 1029
VL  - 35
IS  - 9
N2  - Orellanine is a nephrotoxic toxin produced by some mushroom species of the Cortinarius genus, typically found in Europe and North America. The nephrotoxicity of Cortinarius orellanus is well known and was first recognized in the 1950s when this mushroom was identified as the cause of a mass poisoning in Poland. Typically, onset of symptoms is delayed for 1-2 weeks after ingestion. Some patients suffer mild gastrointestinal discomfort in the latency period before developing signs of renal impairment due to severe interstitial nephritis, acute focal tubular damage, and interstitial fibrosis. There is no specific antidote to orellanine poisoning. The mainstay of treatment is the prevention of secondary complications of kidney failure, adequate dialysis and, in the case of incomplete recovery, management of chronic renal insufficiency.In this work, we aim to review about Cortinarius species, including epidemiological studies, chemical structure, toxicokinetics, toxic doses, mechanisms of toxicity, diagnosis, prognosis, and treatment options.<p />  <p>Language: en</p>
LA  - en
SN  - 0960-3271
UR  - http://dx.doi.org/10.1177/0960327115613845
ID  - ref1
ER  -