TY  - JOUR
PY  - 2015//
TI  - Curare alkaloids: constituents of a Matis dart poison
JO  - Journal of natural products
A1  - Malca Garcia, Gonzalo R.
A1  - Hennig, Lothar
A1  - Shelukhina, Irina V.
A1  - Kudryavtsev, Denis S.
A1  - Bussmann, Rainer W.
A1  - Tsetlin, Victor I.
A1  - Giannis, Athanassios
SP  - 2537
EP  - 2544
VL  - 78
IS  - 11
N2  - A phytochemical study of dart and arrow poison from the Matis tribe led to the identification of d-(-)-quinic acid, l-malic acid, ethyldimethylamine, magnoflorine, and five new bisbenzyltetrahydroisoquinoline alkaloids (BBIQAs), 1-5. d-Tubocurarine could not be identified among these products. BBIQA (3) contains a unique linkage at C-8 and C-11'. All structures were characterized by a combination of NMR and HRESIMS data. The effects of Matis poison and individual BBIQAs (1-3) on rat muscle nAChR expressed in Xenopus oocytes have been investigated using the two-electrode voltage clamp technique.<p />  <p>Language: en</p>
LA  - en
SN  - 0163-3864
UR  - http://dx.doi.org/10.1021/acs.jnatprod.5b00457
ID  - ref1
ER  -