TY  - JOUR
PY  - 2015//
TI  - Untangling the effect of head acceleration on brain responses to blast waves
JO  - Journal of biomechanical engineering
A1  - Mao, Haojie
A1  - Unnikrishnan, Ginu
A1  - Rakesh, Vineet
A1  - Reifman, Jaques
SP  - 124502
EP  - 124502
VL  - 137
IS  - 12
N2  - Multiple injury-causing mechanisms, such as wave propagation, skull flexure, cavitation, and head acceleration, have been proposed to explain blast-induced traumatic brain injury (bTBI). An accurate, quantitative description of the individual contribution of each of these mechanisms may be necessary to develop preventive strategies against bTBI. However, to date, despite numerous experimental and computational studies of bTBI this question remains elusive. In this study, using a two-dimensional (2-D) rat head model, we quantified the contribution of head acceleration to the biomechanical response of brain tissues when exposed to blast waves in a shock tube. We compared brain pressure at the coup, middle, and contre-coup regions between a 2-D rat head model capable of simulating all mechanisms (i.e., the all-effects model) and an acceleration-only model. From our simulations, we determined that head acceleration contributed 36-45% of the maximum brain pressure at the coup region, had a negligible effect on the pressure at the middle region, and was responsible for the low pressure at the contre-coup region. Our findings also demonstrate that the current practice of measuring rat brain pressures close to the center of the brain would record only two-thirds of the maximum pressure observed at the coup region. Therefore, to accurately capture the effects of acceleration in experiments, we recommend placing a pressure sensor near the coup region, especially when investigating the acceleration mechanism using different experimental set-ups.<p />  <p>Language: en</p>
LA  - en
SN  - 0148-0731
UR  - http://dx.doi.org/10.1115/1.4031765
ID  - ref1
ER  -