TY  - JOUR
PY  - 2015//
TI  - Anxiety symptoms are linked to new-onset suicidal ideation after six months of follow-up in outpatients with major depressive disorder
JO  - Journal of affective disorders
A1  - Baek, Ji Hyun
A1  - Yoon Heo, Jung
A1  - Fava, Maurizio
A1  - Mischoulon, David
A1  - Nierenberg, Andrew
A1  - Pyo Hong, Jin
A1  - Won Roh, Sung
A1  - Jin Jeon, Hong
SP  - 183
EP  - 187
VL  - 187
IS  - 
N2  - BACKGROUND: Suicide risk evaluation is one of the most challenging assessments of patients with major depressive disorder (MDD). Initial risk evaluation might be insufficient in predicting emergence of suicidal ideation during the maintenance period. We aimed to elucidate factors associated with emergence or persistence of suicidal ideation 6 months after initiation of outpatient treatment in patients with MDD. <br><br>METHODS: A total of 300 participants with MDD defined by DSM-IV-TR criteria underwent face-to-face interview at baseline and follow-up phone interview at 6 months later. Severity of depression, suicidal ideation, and anxiety were evaluated. <br><br>RESULTS: Among participants who did not report any suicidal idea at baseline, 10.9% reported suicidal ideation during the 6-month phone interview, while 28.4% of participants who reported suicidal ideation at baseline reported suicidal ideation during the phone interview. No significant difference in remission rate of depression was observed between the groups, but subjects without suicidal ideation at baseline had a higher rate of symptom improvement at the 6-month phone interview. After controlling for age, sex, baseline severity of suicide risk and depression and lifetime history of suicide attempts, emergence of suicidal ideation was significantly associated with anxiety level at baseline (t=2.127, p=0.039) and severity of depression symptoms at 6 month (t=-3.028, p=0.004); persistence of suicidal ideation was associated with severity of depression symptoms at 6 month (t=-4.962, p<0.001). LIMITATION: Follow-up evaluation was done by phone interview. <br><br>CONCLUSION: Anxiety at baseline needs to be carefully evaluated in assessing suicide risk of patients with MDD.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2015.08.006
ID  - ref1
ER  -