TY  - JOUR
PY  - 2013//
TI  - Fractures at diagnosis in infants and children with osteogenesis imperfecta
JO  - Journal of pediatric orthopedics
A1  - Greeley, Christopher Spencer
A1  - Donaruma-Kwoh, Marcella
A1  - Vettimattam, Melanie
A1  - Lobo, Christine
A1  - Williard, Coco
A1  - Mazur, Lynnette
SP  - 32
EP  - 36
VL  - 33
IS  - 1
N2  - BACKGROUND: In infants and children with fractures from an unclear cause, osteogenesis imperfecta (OI) is often included as a potential etiology. In infants and children with OI there exists a gap in the published literature regarding the fracture pattern seen at the time of diagnosis. As an additional aid to the diagnosis of OI, we sought to characterize the fracture patterns in infants and children at the time of their diagnosis. <br><br>METHODS: We performed a retrospective chart review of a series of infants and children under 18 years of age who have the diagnosis of OI (any type) from a single institution. <br><br>RESULTS: We identified 68 infants and children with OI: 23 (34%) type 1, 1 (2%) type 2, 17 (25%) type 3, 24 (35%) type 4, and 3 (4%) unknown type. A family history of OI was present in 46% of children. Forty-nine (72.0%) patients were diagnosed solely on clinical characteristics, without genetic or fibroblast confirmation. Rib fractures were noted in 21% of the subjects with none being identified during infancy. The number of fractures identified at diagnosis ranged from 1 to >37 with 7 (10%) having more than 2 fractures. All subjects with more than 2 fractures were diagnosed prenatally or in the immediate newborn period. Seventeen (25%) infants were diagnosed after 1 week of age but before 12 months of age. None of these infants had either rib fractures or more than 1 fracture at the time of diagnosis. <br><br>CONCLUSIONS: The majority of children diagnosed with OI are diagnosed by clinical features alone. The fracture pattern at the time of diagnosis in OI is variable with 10% having more than 2 fractures. The diagnosis of OI was made in utero or at delivery in 43% of children. Multiple rib fractures in an infant would be an unexpected finding in OI. LEVEL OF EVIDENCE: Level III.<p /> <p>Language: en</p>
LA  - en
SN  - 0271-6798
UR  - http://dx.doi.org/10.1097/BPO.0b013e318279c55d
ID  - ref1
ER  -