TY  - JOUR
PY  - 1996//
TI  - Effects of fluoxetine on play dominance in juvenile rats
JO  - Aggressive behavior
A1  - Knutson, B
A1  - Panksepp, J.
A1  - Pruitt, D
SP  - 297
EP  - 307
VL  - 22
IS  - 4
N2  - In a series of three studies, we investigated the influence of a selective serotonin reuptake inhibitor (fluoxetine) on the rough-and-tumble play of juvenile rats. In Experiment 1, both members of eight pairs of solitary-housed juvenile rats received either vehicle, 2.5, 5, or 10 mg/kg fluoxetine in a counterbalanced within-subject design 20 min before being allowed to play for 5 min periods on four successive test days. The 5 and 10 mg/kg pretreatments significantly reduced incidence of pins during play without affecting dorsal contacts. In Experiment 2, one member of each of 19 established play pairs received 5 mg/kg fluoxetine 20 min before play, while the other member received vehicle. Dominant rats showed no reduction in pins as a result of fluoxetine treatment, but subordinate rats who received fluoxetine exhibited significant reductions in pins. Subsequent dyadic analyses indicated that in pairs where the subordinate animal received fluoxetine, dominant animals maintained their pinning advantage over the 10 days of testing, but in pairs where the dominant animals received fluoxetine, this pinning asymmetry diminished. In Experiment 3, we replicated the above procedure with inexperienced play pairs, to control for the effects of prior social learning. Fluoxetine treatment (5 mg/kg) significantly reduced both pins and dorsal contacts in all treated rats. The results indicate that fluoxetine can reduce the playful pins of juvenile rats, but that prior social learning mediates the strength of these effects..<p />
LA  - en
SN  - 0096-140X
UR  - http://dx.doi.org/
ID  - ref1
ER  -