TY  - JOUR
PY  - 2015//
TI  - The association between obstructive sleep apnea and metabolic markers and lipid profiles
JO  - PLoS one
A1  - Wu, Wei-Te
A1  - Tsai, Su-Shan
A1  - Shih, Tung-Sheng
A1  - Lin, Ming-Hsiu
A1  - Chou, Tzu-Chieh
A1  - Ting, Hua
A1  - Wu, Trong-Neng
A1  - Liou, Saou-Hsing
SP  - e0130279
EP  - e0130279
VL  - 10
IS  - 6
N2  - PURPOSE: The purpose of this study was to investigate the association between apnea-hypopnea index (AHI) and metabolic markers and whether the elevated risk of Metabolic Syndrome (MetS) is related to Obstructive Sleep Apnea (OSA). <br><br>METHODS: This cross-sectional study recruited 246 male bus drivers from one transportation company in Taiwan. Each participant was evaluated by a polysomnography (PSG) test and by blood lipids examination. Severity of OSA was categorized according to the apnea-hypopnea index (AHI). <br><br>RESULTS: The results showed that a 73.3% prevalence of MetS in OSA (AHI > 15) and a 80.0% prevalence of MetS in severe OSA (AHI > 30) were found. After adjusting for confounding variables, an increased level of Body-Mass Index (BMI) and two non-MetS cardiovascular risk factors, total cholesterol/HDL-C ratio and TG/HDL-C ratio was significantly associated with AHI in subjects with severe OSA. MetS was about three times to be present in subjects with severe OSA, even adjusted for BMI. <br><br>CONCLUSIONS: The findings showed a high prevalence of MetS in OSA among professional drivers, especially in the severe group category. BMI was the major contributing factor to OSA. However, the present study did not find a sensitive clinical marker of a detrimental metabolic profile in OSA patients.<p />  <p>Language: en</p>
LA  - en
SN  - 1932-6203
UR  - http://dx.doi.org/10.1371/journal.pone.0130279
ID  - ref1
ER  -