TY  - JOUR
PY  - 2015//
TI  - Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk
JO  - Journal of affective disorders
A1  - Wiener, Carolina David
A1  - de Mello Ferreira, Sharon
A1  - Pedrotti Moreira, Fernanda
A1  - Bittencourt, Guilherme
A1  - de Oliveira, Jacqueline Flores
A1  - Lopez Molina, Mariane
A1  - Jansen, Karen
A1  - de Mattos Souza, Luciano Dias
A1  - Rizzato Lara, Diogo
A1  - Portela, Luiz Valmor
A1  - da Silva, Ricardo Azevedo
A1  - Oses, Jean Pierre
SP  - 245
EP  - 248
VL  - 184
IS  - 
N2  - Nerve growth factor (NGF) is an important member of the neurotrophins group and their involvement in the pathophysiology of major depression disorder (MDD) and suicide risk (SR) has been recently suggested. The aim of this study is to evaluate the changes in NGF serum levels in individuals with MDD and with or without risk of suicide, in subjects from a young population-based sample. This is a paired cross-sectional study nested in a population-based study. Individuals were rated for MDD and SR by a diagnostic interview - Mini International Neuropsychiatric Interview (M.I.N.I). The total population of the sample was comprised of 141 subjects distributed in three groups: 47 healthy controls, 47 subjects with current depressive episode without SR (MDD) and 47 subjects with current depressive episode and with SR (MDD+SR). NGF serum levels were significantly reduced in the MDD and MDD+SR groups when compared with controls (p≤0.001). However, there were no differences in NGF levels between the MDD and MDD+SR groups (p=1.000). These results suggest that reduced NGF serum levels can be a possible biomarker of MDD.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2015.05.067
ID  - ref1
ER  -