TY  - JOUR
PY  - 2015//
TI  - A genome-wide copy number variant study of suicidal behavior
JO  - PLoS one
A1  - Gross, Jeffrey A.
A1  - Bureau, Alexandre
A1  - Croteau, Jordie
A1  - Galfalvy, Hanga
A1  - Oquendo, Maria A.
A1  - Haghighi, Fatemeh
A1  - Mérette, Chantal
A1  - Giegling, Ina
A1  - Hodgkinson, Colin
A1  - Goldman, David
A1  - Rujescu, Dan
A1  - Mann, J. John
A1  - Turecki, Gustavo
SP  - e0128369
EP  - e0128369
VL  - 10
IS  - 5
N2  - Suicide and suicide attempts are complex behaviors that result from the interaction of different factors, including genetic variants that increase the predisposition to suicidal behaviors. Copy number variations (CNVs) are deletions or duplications of a segment of DNA usually larger than one kilobase. These structural genetic changes, although quite rare, have been associated with genetic liability to mental disorders, such as autism, schizophrenia, and bipolar disorder. No genome-wide level studies have been published investigating the potential role of CNVs in suicidal behaviors. Based on single-nucleotide polymorphism array data, we followed the Penn-CNV standards to detect CNVs in 1,608 subjects, comprising 475 suicide and suicide attempt cases and 1,133 controls. Although the initial algorithms determined the presence of CNVs on chromosomes 6 and 12 in seven and eight cases, respectively, compared with none of the controls, visual inspection of the raw data did not support this finding. Furthermore we were unable to validate these findings by CNV-specific real-time polymerase chain reaction. Additionally, rare CNV burden analysis did not find an association between the frequency or length of rare CNVs and suicidal behavior in our sample population. Although our findings suggest CNVs do not play an important role in the etiology of suicidal behaviors, they are not inconsistent with the strong evidence from the literature suggesting that other genetic variants account for a portion of the total phenotypic variability in suicidal behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 1932-6203
UR  - http://dx.doi.org/10.1371/journal.pone.0128369
ID  - ref1
ER  -