TY  - JOUR
PY  - 2015//
TI  - Cavum septum pellucidum in retired American pro-football players
JO  - Journal of neurotrauma
A1  - Gardner, Raquel C.
A1  - Hess, Christopher P.
A1  - Brus-Ramer, Marcel C.
A1  - Possin, Katherine C.
A1  - Cohn-Sheehy, Brendan I.
A1  - Kramer, Joel H.
A1  - Berger, Mitchel
A1  - Yaffe, Kristine C.
A1  - Miller, Bruce
A1  - Rabinovici, Gil D.
SP  - 157
EP  - 161
VL  - 33
IS  - 1
N2  - Prior studies report that cavum septum pellucidum (CSP) is frequent among athletes with a history of repeated traumatic brain injury (TBI), such as boxers. Few studies of CSP in athletes, however, have assessed detailed features of the septum pellucidum in a case-control fashion. This is important because prevalence of CSP in the general population varies widely (2% to 85%) between studies. Furthermore, rates of CSP among American pro-football players have not been previously described. We sought to characterize MRI features of the septum pellucidum in a series of retired pro-football players with a history of repeated concussive/sub-concussive head traumas compared to controls. We retrospectively assessed retired American pro-football players presenting to our memory clinic with cognitive/behavioral symptoms in whom structural MRI was available with slice thickness ≤2mm (n= 17). Each player was matched to a memory clinic control patient with no history of TBI. Scans were interpreted by raters blinded to clinical information and TBI/football history, who measured CSP grade (0-absent, 1-equivocal, 2-mild, 3-moderate, 4-severe) and length according to a standard protocol. 16/17 players (94%) had a CSP graded ≥2 compared to 3/17 controls (18%). CSP was significantly higher grade (p<0.001) and longer in players than controls (mean length ±SD: 10.6mm ±5.4 vs. 1.1mm ±1.3, p<0.001). Among patients presenting to a memory clinic, long high-grade CSP was more frequent in retired pro-football players compared to patients without a history of TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2014.3805
ID  - ref1
ER  -