TY  - JOUR
PY  - 2015//
TI  - Differences in regional brain volumes two months and one year after mild traumatic brain injury
JO  - Journal of neurotrauma
A1  - Zagorchev, Lyubomir
A1  - Meyer, Carsten
A1  - Stehle, Thomas
A1  - Wenzel, Fabian
A1  - Young, Stewart
A1  - Peters, Jochen
A1  - Weese, Juergen
A1  - Paulsen, Keith D.
A1  - Garlinghouse, Matthew
A1  - Ford, James
A1  - Roth, Robert
A1  - Flashman, Laura A.
A1  - McAllister, Thomas
SP  - 29
EP  - 34
VL  - 33
IS  - 1
N2  - Conventional structural imaging is often normal after mild Traumatic Brain Injury (mTBI). There is a need for structural neuroimaging biomarkers that facilitate detection of milder injuries, allow recovery trajectory monitoring, and identify those at risk for poor functional outcome and disability. We present a novel approach to quantifying volumes of candidate brain regions at risk for injury. Compared to controls, mTBI patients had significantly smaller volumes in several regions including the caudate, putamen, and thalamus when assessed two months after injury. These differences persisted but were reduced in magnitude one year after injury, suggesting the possibility of normalization over time in the affected regions. However more pronounced differences were found in the amygdala and hippocampus suggesting the possibility of regionally specific responses to injury.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2014.3831
ID  - ref1
ER  -