TY  - JOUR
PY  - 2015//
TI  - A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression
JO  - Journal of neurochemistry
A1  - Gulbins, Erich
A1  - Walter, Silke
A1  - Becker, Katrin Anne
A1  - Halmer, Ramona
A1  - Liu, Yang
A1  - Reichel, Martin
A1  - Edwards, Michael J.
A1  - Müller, Christian P.
A1  - Fassbender, Klaus
A1  - Kornhuber, Johannes
SP  - 183
EP  - 192
VL  - 134
IS  - 2
N2  - Major depressive disorder is a severe and chronic illness with high lifetime prevalence and a high incidence of suicide as the cause of death for patients with this diagnosis. Major depressive disorder is often treated with antidepressants. Although these drugs have been used for many years, their exact mode of action is still unknown. It has been suggested that many antidepressants act by increasing the concentrations of serotonergic transmitters in the synaptic space. However, recent studies have examined the effects of antidepressants on neurogenesis in the hippocampus, the restoration of hippocampal neuronal networks that may be affected by major depression, and the regulation of the hypothalamic-pituitary-adrenal axis by immature neurons in the hippocampus. Here we present and discuss a novel hypothesis suggesting that these events are regulated by the concentrations of sphingolipids, in particular ceramide, in the hippocampus. These concepts suggest that the acid sphingomyelinase/ceramide system plays a central role in the pathogenesis of major depression and may be a novel target for antidepressants. This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3042
UR  - http://dx.doi.org/10.1111/jnc.13145
ID  - ref1
ER  -